Objective: To investigate the status and existing problems of drug manipulation for oral dosing in neonatology department of Huzhou Maternal & Child Health-Care Hospital

to put forward rational suggestions

so as to provide reference for clinical drug use. Methods: Statistical analysis was performed on medical orders of drug manipulation for oral dosing in neonatology department from 2017 to 2019

including frequency of use

dose specification and dosing method

and literature analysis was conducted. Results: There were 12 kinds of oral drugs in neonatology department

accounting for 6.22% of all oral drugs in our hospital. The dosing methods included direct breaking

grinding and sub-packaging

temporary preparation of liquid preparations

and visual estimation of granules and powders. Conclusion: There are still various problems in dose accuracy

microorganism limited

drug storage stability and safety during the process of drug manipulation. Suitable drug manipulation methods should be selected according to the characteristics of drugs

and the standard process of drug manipulation should be explored to help improve the safety and effectiveness of medication in neonates.